Superspreading genomes

Ebola superspreading.

Superspreading SARS Events, Beijing, 2003

Superspreading events were pivotal in the global spread of severe acute respiratory syndrome (SARS). We investigated superspreading in one transmission chain early in Beijing's epidemic. Superspreading was defined as transmission of SARS to at least eight contacts. An index patient with onset of SARS 2 months after hospital admission was the source of four generations of transmission to 76 case...

An event-based model of superspreading in epidemics.

Many recent disease outbreaks (e.g. SARS, foot-and-mouth disease) exhibit superspreading, where relatively few individuals cause a large number of secondary cases. Epidemic models have previously treated this as a demographic phenomenon where each individual has an infectivity allocated at random from some distribution. Here, it is shown that superspreading can also be regarded as being caused ...

Superspreading and the impact of individual variation on disease emergence

Supplementary Table 1 A summary of results from our statistical analysis of uncontrolled outbreaks, corresponding to the results shown in Figure 1a-c of the main article. Supplementary Table 2 Detailed results from our statistical analysis of uncontrolled outbreaks (elaborating on the summary shown in Supplementary Table 1), and from the analysis of data from four outbreaks before and after con...

The effect of superspreading on epidemic outbreak size distributions.

Recently, evidence has been presented to suggest that there are significant heterogeneities in the transmission of communicable diseases. Here, a stochastic simulation model of an epidemic process that allows for these heterogeneities is used to demonstrate the potentially considerable effect that heterogeneity of transmission will have on epidemic outbreak size distributions. Our simulation re...